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HomeAboutAboutHow TRUMENBA WorksTru Patient StoriesAre Your Patients Protected?CDC RecommendationsDosingEfficacy & SafetyEfficacy & SafetySafety Profile and TolerabilityImmunogenicity & PersistenceSupport & OrderSupport & OrderWelcome to TruSupportOrdering & InventoryCoverage & ReimbursementPatient Adherence
Prescribing InformationIndicationMedical Information
Dosing and CoadministrationTRUMENBA offers a 2-dose option for adolescent and young adult patients.1*

Not actual patients. For illustrative purposes only.

  • If the second dose is administered earlier than 6 months after the first dose, a third dose should be administered at least 4 months after the second dose1

The Advisory Committee on Immunization Practices (ACIP) recommends the 2 doses for persons aged 16 through 23 years who are not at increased risk for meningococcal disease, based on shared clinical decision-making.2

On average, young adults return to the doctor after 6 to 8 months.3†

ACIP recommends the 3-dose schedule for persons aged ≥10 years who are in a MenB outbreak situation or at increased risk for meningococcal disease.2

These persons include those with persistent complement component deficiencies, those with anatomic or functional asplenia, or microbiologists routinely exposed to isolates of Neisseria meningitidis.1,2

The choice of dosing schedule may depend on the risk of exposure and the patient’s susceptibility to meningococcal serogroup B disease.1Data collected in March 2017 from a survey of 593 young adults (aged 16-21 years) and/or patients/caregivers across the United States.Including inherited or chronic deficiencies in C3, C5-9, properdin, factor D, factor H, or who are taking eculizumab (Soliris®; Alexion Pharmaceuticals, Inc.)Only TRUMENBA has been studied with 3 other adolescent vaccines1,2
  • Concomitant administration did not significantly increase local reactions or systemic events compared with TRUMENBA alone4,5
The immunogenicity of concomitantly administered TRUMENBA with HPV4, MenACWY, and Tdap vaccines was evaluated in adolescents.1,2
  • The noninferiority criteria were met for all immunogenicity endpoints for MenB strains and MenACWY and Tdap antigens, as well as HPV antigens except HPV-181
  • Seroconversion for all 4 HPV antigens was achieved by ≥99% of subjects in the groups that received HPV4 (secondary endpoint)4

Data are not available to assess the safety and immunogenicity of concomitant administration of TRUMENBA with other routine adolescent vaccines.1​​​​​​

fHbp=factor H binding protein; HPV4=quadrivalent human papillomavirus vaccine; HPV=human papillomavirus; MenACWY=quadrivalent (serogroups A, C, W, Y) meningococcal conjugate vaccine; MenB=serogroup B meningococcal disease; Tdap=tetanus, diphtheria, and pertussis vaccine.TitleContact your Pfizer Sales Representative or call a Vaccine Specialist at ​​​1-844-439-2571.References:TRUMENBA [package insert]. Philadelphia, PA: Pfizer Inc.; 2021.Mbaeyi SA, Bozio CH, Duffy J, et al. Meningococcal vaccination: recommendations of the Advisory Committee on Immunization Practices, United States, 2020. MMWR Recomm Rep. 2020;69(9):1-41.QuintilesIMS primary market research study, 2017.Senders S, Bhuyan P, Jiang Q, et al. Immunogenicity, tolerability and safety in adolescents of bivalent rLP2086, a meningococcal serogroup B vaccine, coadministered with quadrivalent human papilloma virus vaccine. Pediatr Infect Disease J. 2016;35(5):548-554.Muse D, Christensen S, Bhuyan P, et al. A phase 2, randomized, active-controlled, observer-blinded study to assess the immunogenicity, tolerability and safety of bivalent rLP2086, a meningococcal serogroup B vaccine, coadministered with tetanus, diphtheria and acellular pertussis vaccine and serogroup A, C, Y and W-135 meningococcal conjugate vaccine in healthy US adolescents. Pediatr Infect Dis J. 2016;35(6):673-682.Centers for Disease Control and Prevention. Meningococcal disease. Centers for Disease Control and Prevention website. http://www.cdc.gov/meningococcal/index.html. Updated January 21, 2020. Accessed October 21, 2021.Tully J, Viner RM, Coen PG, et al. Risk and protective factors for meningococcal disease in adolescents: matched cohort study. BMJ. 2006;332(7539):445-450.Dwilow R, Fanella S. Invasive meningococcal disease in the 21st century—an update for the clinician. Curr Neurol Neurosci Rep. 2015;15(2):1-9.Balmer P, Burman C, Serra L, York LJ. Impact of meningococcal vaccination on carriage and disease transmission: a review of the literature. Hum Vaccin Immunother. 2018;14(5):1118-1130.Wang X, Cohn A, Comanducci M, et al. Prevalence and genetic diversity of candidate vaccine antigens among invasive Neisseria meningitidis isolates in the United States. Vaccine. 2011;29{29-30):4739-4744.
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Why adolescents and young adults?

Typical adolescent and young adult behaviors increase MenB risk.6-9

Learn more about MenBLoading
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The science behind TRUMENBA

Only TRUMENBA targets both subfamilies, A and B, of fHbp.1,10

See the scienceLoading

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INDICATION
  • Trumenba is a vaccine indicated for active immunization to prevent invasive disease caused by Neisseria meningitidis serogroup B. Trumenba is approved for use in individuals 10 through 25 years of age
Important Safety Information
  • Severe allergic reaction (eg, anaphylaxis) to any component of Trumenba is a contraindication
  • Some individuals with altered immunocompetence may have reduced immune responses to Trumenba
  • Persons with certain complement deficiencies and persons receiving treatment that inhibits terminal complement activation (for example, eculizumab) are at increased risk for invasive disease caused by Neisseria meningitidis serogroup B even if they develop antibodies following vaccination with Trumenba
  • Vaccination with Trumenba may not protect all vaccine recipients against N meningitidis serogroup B infections
  • Syncope (fainting) can occur in association with administration of injectable vaccines, including Trumenba. Procedures should be in place to avoid injury from fainting
  • In clinical studies, the most common solicited adverse reactions in adolescents and young adults were pain at injection site (≥85%), fatigue (≥60%), headache (≥55%), and muscle pain (≥35%) 
  • Data are not available on the safety and effectiveness of using Trumenba and other meningococcal group B vaccines interchangeably to complete the vaccination series
  • Safety and effectiveness have not been established in pregnant women
Indication
  • Trumenba is a vaccine indicated for active immunization to prevent invasive disease caused by Neisseria meningitidis serogroup B. Trumenba is approved for use in individuals 10 through 25 years of age
Please see full Prescribing Information.

Please see full Prescribing Information.

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